Medicament for topical use

Details Medicament for topical use Medicament for topical use

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/7036 (2006.01) A61K 45/06 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2635992

A pharmaceutical composition comprises (a) an antibacterial agent in an antibacterially effective amount, illustratively comprising clindamycin or a pharmaceutically acceptable salt or ester thereof; and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.

L'invention concerne une composition pharmaceutique contenant (a) une quantité efficace d'un point de vue antibactérien d'un agent antibactérien comprenant de la clindamycine ou un sel ou un ester acceptable d'un point de vue pharmaceutique de celui-ci; et (b) une quantité efficace d'un point de vue antifongique d'un agent antifongique comprenant du butoconazole ou un sel ou un ester acceptable d'un point de vue pharmaceutique de celui-ci. Cette composition est adaptée pour être appliquée en une dose unitaire sur une surface vulvo-vaginale, et comprend au moins une phase interne non lipidique et au moins une phase externe lipidique bioadhésive sur la surface vulvo-vaginale. Ladite composition est administrée sur une surface vulvo-vaginale pour traiter une infection mélangée à vaginose bactérienne et candidose vulvo-vaginale.

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