A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/34 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01) A61L 29/08 (2006.01) A61L 31/10 (2006.01) A61L 31/14 (2006.01)
Patent
CA 2419379
A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.
L'invention concerne une composition de revêtement, à la fois sous sa forme non réticulée et réticulée, destinée à la distribution d'un médicament depuis la surface d'un dispositif médical placé <i>in vivo</i>. Une fois réticulée, la composition de revêtement forme une matrice gel pouvant renfermer le médicament sous une forme permettant sa distribution depuis la matrice de façon prolongée, régulée, prévisible et efficace, <i>in vivo</i>. Une composition de l'invention renferme un polyéther monomère, tel qu'un alcoxy polyalkylèneglycol, un monomère contenant de l'acide carboxylique, tel que l'acide methacrylique, un monomère photodérivatisé, et un monomère hydrophile, tel que l'acrylamide.
Amos Richard A.
Chudzik Stephen J.
Everson Terrence P.
Sim & Mcburney
Surmodics Inc.
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