Medicament inhibiting sodium/calcium exchange system

Details Medicament inhibiting sodium/calcium exchange system Medicament inhibiting sodium/calcium exchange system

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2454681

A medicament for inhibiting sodium/calcium exchange system which comprises as an active ingredient a substance selected from the group consisting of an aminobenzenesulfonic acid derivative represented by the following general formula (I) and a salt thereof, and a hydrate thereof and a solvate thereof: wherein R1 represents a hydrogen atom, a C1-C6 alkyl group and the like; R2 represents a hydrogen atom, a C1-C6 alkyl group, or a C7-C12 aralkyl group; and n represents an integer of from 1 to 4. The medicament is useful for suppression of intracellular calcium accumulation generated under very severe dyscrasic condition as a result of clinically-occurred combination of ischemia/reperfusion and intracellular sodium increase.

L'invention concerne un médicament inhibant un système d'échange de sodium/calcium comprenant, comme principe actif, une substance sélectionnée dans le groupe constitué d'un dérivé d'acide aminobenzènesulfonique représentée par la formule générale suivante (I) et son sel, et son hydrate et son solvate, dans laquelle R¿1? représente un atome d'hydrogène, un groupe alkyle C¿1?-C¿6? et analogue; R¿2? représente un atome d'hydrogène, un groupe alkyle C¿1?-C¿6? ou un groupe aralkyle C¿7?-C¿12?; et n représente un entier allant de 1 à 4. Le médicament sert à supprimer l'accumulation de calcium intracellulaire générée dans des conditions très graves de dyscrasie faisant suite à la combinaison clinique d'ischémie/reperfusion et d'augmentation du sodium intracellulaire.

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