Medicaments and methods for inhibition of scarring

Details Medicaments and methods for inhibition of scarring Medicaments and methods for inhibition of scarring

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2726442

Provided is the use of an agonist of a GABA A receptor for use in the prevention, reduction or inhibition of scarring formed on healing of a wound. Also provided is a method of preventing, reducing or inhibiting scarring formed on healing of a wound, in which a therapeutically effective amount of an agonist of a GABA A receptor is administered to a patient in need of such prevention, reduction or inhibition. The GABA A receptor agonist used may be an agonist specific to the GABA A receptor, such as Gaboxadol (7-tetra hydroisoxazolo[5, 4-c]pyridin-3-ol), or a pharmaceutically acceptable salt thereof. The scarring to be prevented, reduced or inhibited may be scarring formed on healing of a wound of the dermis.

Linvention concerne lutilisation dun agoniste dun récepteur de GABAA pour utilisation dans la prévention, la réduction ou linhibition de la formation dune cicatrice formée lors de la guérison dune plaie. Linvention concerne également une méthode de prévention, de réduction ou dinhibition de la formation dune cicatrice formée lors de la guérison dune plaie, dans laquelle une quantité dun point de vue thérapeutique efficace dun agoniste dun récepteur de GABAA est administrée à un patient nécessitant une telle prévention, réduction ou inhibition. Lagoniste du récepteur de GABAA utilisé peut être un agoniste spécifique au récepteur de GABAA, comme du Gaboxadol (7-tétra hydroisoxazolo[5, 4-c]pyridin-3-ol) ou un sel pharmaceutiquement acceptable de celui-ci. La cicatrice à empêcher, à réduire ou à inhiber peut être une cicatrice formée lors de la guérison dune plaie du derme.

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