Medicaments and methods for promoting wound contraction

Details Medicaments and methods for promoting wound contraction Medicaments and methods for promoting wound contraction

A - Human Necessities

61

K

A61K 31/57 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2673713

Provided are antagonists of FXR activity for use as medicament for the prevention, reduction or inhibition of scarring. This use may preferably be to prevent, reduce or inhibit scarring formed on healing of wounds. The invention also provides corresponding methods of treatment. Preferred antagonists of FXR activity include guggulsterone (Z); guggulsterone (E); a scalarane; 80-574; and a 5.alpha.-bile alcohol. In advantageous embodiments, up to 32 µM of the antagonist of FXR activity may be provided per linear cm of wound, or cm2 of a wound or fibrotic disorder, over a 24 hour period in order to inhibit scarring.

L'invention concerne des antagonistes de l'activité FXR destinés à être utilisés en tant que médicament pour la prévention, la réduction ou l'inhibition de la cicatrisation. Cette utilisation peut, de préférence, consister à empêcher, réduire ou inhiber la cicatrisation formée lors de la guérison de plaies. L'invention concerne également des procédés de traitement correspondants. Des antagonistes préférés de l'activité FXR comprennent la guggulstérone (Z); la guggulstérone (E); une scalarane; 80-574; et un alcool 5.alpha.-biliaire. Dans des modes de réalisation avantageux, jusqu'à 32 µM de l'antagoniste de l'activité FXR peuvent être fournies par cm linéaire de plaie, ou cm2 d'une plaie ou d'un trouble fibrotique, pendant une période de 24 heures afin d'inhiber la cicatrisation.

Affiliated with

Also associated with

Rating

Medicaments and methods for promoting wound contraction does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Medicaments and methods for promoting wound contraction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Medicaments and methods for promoting wound contraction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1731046