Medicaments containing 5-alkyl-pyrimidine nucleosides and...

Details Medicaments containing 5-alkyl-pyrimidine nucleosides and... Medicaments containing 5-alkyl-pyrimidine nucleosides and...

A - Human Necessities

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A61K 31/70 (2006.01) A61K 31/10 (2006.01) A61K 31/505 (2006.01) C07H 19/06 (2006.01) C07H 19/067 (2006.01) C07H 19/073 (2006.01)

Patent

CA 1162853

ABSTRACT OF THE DISCLOSURE 5-Alkyl-pyrimidine nucleosides of the formula: Image ( I ) in which R represents alkyl having 2 to 10 carbon atoms, x represents hydrogen or hydroxy and y represents a variety of functional carbonyl-containing groups are disclosed for use in medicaments for the treatment of malignant diseases, in immunosuppressive therapy, and as cytostatic and virostatic agents. They may also be used for potentiating the action of 5-fluorouracil. Also disclosed are medicaments containing a 5-alkyl-pyrimidine nucleoside of formula I, either alone or in combination with 5-fluorouracil, in a pharmaceutically acceptable carrier.

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