Medicaments containing as active substance...

A - Human Necessities – 61 – K

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167/141, 167/263

A61K 31/19 (2006.01) A61K 31/355 (2006.01) A61K 31/385 (2006.01) A61K 31/51 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2029599

Medicaments are disclsoed that contain at least one compound of formula I, (see fig.I) where X is a hydrogen atom or both X represent a simple bond between the two sulphur atoms; Y is hydrogen or C1-C6-alkyl and n represents a number from 1 to 10 or their therapeutically acceptable salts with the exception of .alpha.-lipoic acid and dihydrolipoic acid, wherein the dosage unit for solid or semi-solid formulations contains 20 mg to 6 g of the total amount of active substance I, or solutions, suspensions or emulsions which contain 0.2 mg to 800 mg per ml per ml of the total amount of active substance I or a pharmaceutically acceptable salt thereof. These medicaments are for example suitable for combatting retroviruses (for example HIV viruses) and also disorders caused by retroviruses.

Les médicaments faisant l'objet de la présente divulgation renferment au moins un composé correspondant à la formule I (voir fig.1) dans laquelle X est un atome d'hydrogène ou les deux X représentent une liaison simple entre les deux atomes de soufre; Y est un hydrogène ou un alkyle en C1-C6 et n représente un nombre compris entre 1 et 10 ou leurs sels acceptables sur le plan thérapeutique à l'exception de l'acide alpha-lipoïque ou de l'acide dihydrolipoïque, dans lequel la dose pour les formulations solides ou semi-solides renferment de 20 mg à 6 g de la quantité totale de la substance active I, ou des solutions, des suspensions ou des émulsions renfermant 0,2 mg à 800 mg par mL de la quantité totale de la substance active I ou un sel acceptable sur le plan pharmaceutique de leurs sels. Ces médicaments servent par exemple à lutter contre des rétrovirus (par exemple les virus AI) et les affections causées par les rétrovirus.

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