C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 39/21 (2006.01) C07K 14/16 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2325345
The invention relates to compounds containing an amino acid with the sequence X1-Y-X2-D-D-X3 or a nucleic acid coding this amino acid, X1 being at least one chosen amino acid, Y being tyrosine, X2 being an amino acid chosen from the following group: valine, isoleucine and leucine; D being aspartate and X3 being at least one other chosen amino acid, the following amino acids being excluded: TLVLQYVDDLLL and ILVLQYVDDLLL, T being threonine, V being valine, I being isoleucine, L being leucine and Q being glutamine. The invention also relates to medicaments for inducing cytotoxic T-cells, containing this class of compounds.
L'invention concerne des composés comprenant un acide aminé ou un acide nucléique codant pour cet acide aminé, l'acide aminé ayant la séquence ci-après: X1-Y-X2-D-D-X3, où X1 désigne au moins un acide aminé quelconque, Y désigne la tyrosine, X2 désigne un acide aminé choisi dans le groupe comprenant la valine, l'isoleucine et la leucine, D désigne un aspartate, et X3 désigne au moins un autre acide aminé quelconque, à l'exception des séquences d'acides aminés suivantes: TLVLQYVDDLLL et ILVLQYVDDLLL, où T désigne la thréonine, V la valine, I l'isoleucine, L la leucine, et Q la glutamine. L'invention concerne également des médicaments pour l'induction de cellules T cytotoxiques renfermant cette classe de composés.
Harrer Thomas
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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