Medication infusion pump with protein stabilized surface...

Details Medication infusion pump with protein stabilized surface... Medication infusion pump with protein stabilized surface...

A - Human Necessities

61

L

A61L 31/00 (2006.01) A61L 31/10 (2006.01) A61L 33/00 (2006.01) A61M 5/142 (2006.01)

Patent

CA 2241953

A medication infusion pump is provided for use in the delivery of a selected medication to a patient, wherein the pump includes internal surface coatings defining protein stable surfaces. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medication. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such coatings, including direct surface modification, covalent and noncovalent attachment of polymers, and covalent attachment through a saline primer.

Pompe servant à diffuser un produit médicamenteux sélectionné dans le corps d'un patient et dont les surfaces intérieures sont pourvues de revêtements permettant de limiter ou d'éliminer les dépôts de produits protéinés. D'après l'invention, ces surfaces intérieures hydrophiles et des procédés de revêtement correspondants permettent de limiter ou d'éliminer l'accumulation de dépôts de médicaments, ce qui peut se produire lorsqu'on manipule des produits médicamenteux à base de complexes protéinés. Les surfaces préférées hydrophiles de la pompe comprennent des tensioactifs hydrophiles (PEO) ou des revêtements hydrophiles (PEG) présentant des caractéristiques très basses d'adsorption de protéines. Plusieurs procédés servent à fabriquer ces revêtements, y compris la modification directe de surface, la fixation covalente ou non covalente de polymères ou la fixation covalente par l'intermédiaire d'une couche de fond saline.

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