Medicinal aerosol formulations

Details Medicinal aerosol formulations Medicinal aerosol formulations

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 47/22 (2006.01) A61K 31/352 (2006.01) A61K 31/4741 (2006.01)

Patent

CA 2338680

The use of solid, pharmaceutically acceptable salts of cromoglycic acid and/or nedocromil as carriers in a therapeutically and prophylactically inefficacious amount in suspension aerosol formulations of pharmaceutical active compounds improves the dispersion properties, increases the chemical and physical stability of moisture-sensitive active compounds, makes possible a more accurate dosage, in particular even of low-dose active compounds, and as a rule permits the abandonment of surface-active agents.

L'utilisation de sels solides, pharmaceutiquement acceptables, d'acide cromoglicique et/ou de nédocromil comme excipient, dans des proportions non actives sur le plan thérapeutique et prophylactique, dans des formulations d'aérosol en suspension de principes actifs pharmaceutiques, améliore les propriétés de dispersion, accroît la stabilité chimique et physique de principes actifs sensibles à l'humidité, permet un dosage plus précis, notamment de principes actifs même faiblement dosés, et permet en général de renoncer à l'emploi d'agents tensioactifs.

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