Medicinal composition

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 303/36 (2006.01) A61K 31/336 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 21/04 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2515658

(-)-DHM2EQ, which is useful as an antitumor agent and an antiinflammatory agent, can be directly obtained by optically resolving (.plusmn.)-DHM2EQ with the use of an optically active column packed with an optical resolving agent comprising, for example, amylose tris(3,5-dimethylphenylcarbamate) as the active ingredient. The (-)-DHM2EQ obtained by optical resolution with the use of the optically active column or its pharmacologically acceptable salt is useful as a medicinal composition for ameliorating various symptoms.

On peut obtenir directement le (-)-DHM2EQ, agent antitumoral et anti-inflammatoire par résolution optique du (.plusmn.)-DHM2EQ dans une colonne à activité optique remplie d'un agent de résolution optique actif, par exemple de l'amylose tris(3,5-diméthylphénylcarbamate). Le (-)-DHM2EQ ainsi obtenu ou ses sels pharmacocompatibles, constituent des compositions curatives pouvant améliorer différents symptômes.

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