Medicinal composition and method of making same

Details Medicinal composition and method of making same Medicinal composition and method of making same

A - Human Necessities

61

K

167/155

A61K 9/66 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01)

Patent

CA 1200492

MEDICINAL COMPOSITION AND METHOD OF MAKING SAME ABSTRACT A drug delivery system for delivering a pharmaceutical to the brush layer of the small intestine for absorption through the brush layer and for direct passage into the thoracic duct without digestion or breaking up in the stomach and with neither interception by nor reaction with the bile salts of the digestive system. The system involves the formation of an emulsion of oil globules predominantly less than about 1000 .ANG. in diameter in which the pharmaceutical is contained, either dissolved in the oil or dispersed therein in water solution, and the integrity of each globule is maintained by an encasing water layer firmly held in place by surface tension. As a part of the system and to insure proper delivery and protection of the emulsion, e.g. for shelf life and delivery to the stomach, the emulsion is mixed with a water absorbent powder, such as dextran, and the powder is encapsulated in a conventional gelatin capsule. The technique of making the emulsion, of forming a solid composition for filling the capsule, and the composite capsule itself are all disclosed, as well as the unique drug delivery system.

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