Medicinal composition containing diabetes remedy

A - Human Necessities – 61 – K

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Details

A61K 31/7056 (2006.01) A61K 31/198 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 38/28 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2575521

A pharmaceutical composition effective for the prophylaxis and treatment of diabetes is provided. This pharmaceutical composition comprises the combination of an a-amylase inhibitor selected from a compound represented by the following general formula (I): [Chemical formula 1] (see formula I) [wherein A represents, for example, a cyclic group, etc. R1 and R2 represent an alkyl group, hydroxymethyl group, etc., and n represents 1 or 2], or a pharmacologically acceptable salt or ester thereof, and at least one type of drug selected from an insulin sensitizer, an insulin secretagogue, a biguanide drug, an insulin preparation and a DPP-IV inhibitor.

Cette composition médicale est efficace dans la prévention et le traitement du diabète. La composition médicale comprend une combinaison de : un inhibiteur d'.alpha.-amylase choisi parmi un composé représenté par la formule générale suivante (I) : (où A représente un groupe cyclique, etc. ; R1 et R2 représentent chacun de l'alkyle, de l'hydroxylméthyle, etc.; n vaut 1 ou 2) et un sel pharmacologiquement acceptable ou un ester du composé ; au moins un médicament choisi parmi un activateur de sensibilité à l'insuline, un accélérateur de la sécrétion d'insuline, un agent biguanide, une préparation d'insuline et un inhibiteur de DPP-IV.

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