Medicinal composition containing nf-.kappa.b decoy for...

A - Human Necessities – 61 – K

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A61K 45/00 (2006.01) A61K 9/08 (2006.01) A61K 9/12 (2006.01) A61K 9/127 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/30 (2006.01) A61K 48/00 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2531629

A medicinal composition for treating and preventing diseases, disorders and/or conditions of airway inflammation, airway narrowing or nasal cavity inflammation caused by the expression of a gene regulated by NF-.kappa.B which contains an NF-.kappa.B decoy and a pharmaceutically acceptable carrier. The above diseases may be asthma, COPD or rhinitis. Moreover, the above diseases may be diseases caused by abnormality in eosinophils (for example, asthma, rhinitis and COPD). The pharmaceutically acceptable carrier may be a hydrophilic polymer, a liposome and so on.

L'invention concerne une composition médicinale de traitement et de prévention de maladies, de troubles et/ou d'états d'inflammation des voies aériennes, de rétrécissement des voies aériennes ou d'inflammations de la cavité nasale provoqués par l'expression d'un gène régulé par NF-.kappa.B contenant un leurre NF-.kappa.B ainsi qu'un excipient pharmaceutiquement acceptable. Les maladies précitées peuvent être l'asthme, BPCO ou la rhinite. De plus, les maladies précitées peuvent être des maladies provoquées par une anomalie dans les polynucléaires éosinophiles (par exemple, l'asthme, la rhinite et la BPCO). L'excipient pharmaceutiquement acceptable peut être un polymère hydrophile, un liposome, etc..

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