Medicinal composition for prevention or treatment of...

A - Human Necessities – 61 – K

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A61K 31/4045 (2006.01) A61P 13/10 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2557758

A medicinal composition for the prevention or treatment of overactive bladder accompanying nervous disorders. The medicinal composition contains as an active ingredient an indoline derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof. The medicinal composition is useful in the prevention or treatment of overactive bladder accompanying nervous disorders such as cerebrovascular disorder, Parkinson's disease, and myelopathia. In the formula, R represents optionally substituted aliphatic acyl, optionally substituted lower alkyl, optionally substituted aromatic acyl, etc.; R1 represents cyano or carbamoyl; and R2 represents optionally substituted lower alkyl.

Composition thérapeutique destinée à prévenir ou à traiter une vessie hyperactive qui accompagne des troubles nerveux. La composition thérapeutique contient en tant qu~ingrédient actif un dérivé de l~indoline représenté par la formule générale (I) suivante ou un sel pharmacologiquement acceptable de celui-ci. La composition thérapeutique est utile dans le cadre de la prévention ou du traitement d~une vessie hyperactive qui accompagne des troubles nerveux tels qu~une insuffisance cérébrovasculaire, la maladie de Parkinson, et la myélopathie. Dans la formule, R représente un groupe acyle aliphatique éventuellement substitué, un groupe alkyle inférieur éventuellement substitué, un groupe acyle aromatique éventuellement substitué, etc. ; R?1¿ représente un groupe cyano ou carbamoyle ; et R?2¿ représente un groupe alkyle inférieur éventuellement substitué. (I)

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