Medicinal compositions adhering to stomach/duodenum

A - Human Necessities – 61 – K

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Details

A61K 47/30 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2320387

Medicinal compositions adhering to the stomach/duodenum characterized by being obtained by coating a composition containing a drug acting in the stomach and/or duodenum and a component selected from among water-insoluble polymers, polyglycerol fatty acid esters, lipids and waxes with a polymer which is capable of adhering to the surface of the digestive tract mucosa under acidic conditions but strippable therefrom under neutral or alkaline conditions. Use of these compositions adhering exclusively to the gastroduodenal mucosae makes it possible to release drugs over a long period of time, thus achieving sufficient drug effects in a small dose.

L'invention concerne des compositions médicinales adhérant à l'estomac/au duodénum, qui se caractérisent en qu'elles sont produites par l'enrobage d'une composition contenant un médicament agissant dans l'estomac et/ou le duodénum et un composant choisi parmi des polymères insolubles dans l'eau, des esters d'acides gras de polyglycérol, des lipides et des cires, d'un polymère adhérant à la surface de la muqueuse du tube digestif dans des conditions acides, mais pelable dans des conditions neutres ou alcalines. L'utilisation de ces compositions adhérant exclusivement aux muqueuses gastro-duodénale permet la libération de médicaments sur une longue période et une efficacité suffisante du médicament à faible dose.

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