Medicinal compositions and combinations

Details Medicinal compositions and combinations Medicinal compositions and combinations

A - Human Necessities

61

K

A61K 31/4375 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) A61K 45/00 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2548790

Treatment of hyperlipemia or arteriosclerosis either with a composition containing (A) a 3-hydroxy-3-methylglutaryl -coenzyme A reductase inhibitor or a salt thereof and/or ezetimibe or a prodrug or salt thereof and (B) a compound represented by the general formula (1) or a salt thereof or by coadministration of the components (A) and (B) is efficacious even for patients whose blood cholesterol levels could not be satisfactorily lowered with current therapeutic drugs to the target level of treatment, particularly patients in whom coronary heart diseases have appeared. (1) (wherein A is a substituted or unsubstituted pyridine ring; Y is a substituted or unsubstituted aromatic group or the like; R1 is hydrogen, substituted or unsubstituted alkyl, or the like; R2 is hydrogen or lower alkyl; R3 is lower alkyl; and Z is hydroxy, amino, or the like).

L'invention concerne le traitement de l'hyperlipidémie ou de l'artériosclérose, soit au moyen d'une composition contenant (A) un inhibiteur de la 3-hydroxy-3-méthylglutaryl-coenzyme-A réductase ou un sel de celui-ci et/ou de l'ezetimibe ou un promédicament ou un sel de celui-ci, et (B) un composé de formule (1) ou un sel de celui-ci, soit par l'administration conjuguée des composés (A) et (B), ce traitement étant efficace même chez des patients dont les niveaux de cholestérol sanguin n'ont pas pu être ramenés de manière satisfaisante avec des produits thérapeutiques courants au niveau cible de traitement, notamment chez les patients ayant été atteints de maladies coronariennes. (1), où A est un cycle pyridine substitué ou non, Y représente un groupe aromatique substitué ou non ou similaire, R?1¿ signifie hydrogène, alkyle substitué ou non ou similaire, R?2¿ désigne hydrogène ou alkyle inférieur, R?3¿signifie alkyle inférieur, Z représente hydroxy, amino ou similaire.

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