Medicinal compositions for treating cardiac diseases caused...

A - Human Necessities – 61 – K

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A61K 38/22 (2006.01)

Patent

CA 2251155

Medicinal compositions for treating cardiac diseases caused by cardiac hypertrophy, such as cardiac failure, ischemic cardiac diseases and arrhythmia. These compositions contain, as the active ingredient, substances capable of binding to GC-A which is an NP receptor and promoting the production of cGMP. Examples of these active substances include natriuretic peptides such as atrial natriuretic peptides and cerebral natriuretic peptides.

L'invention concerne des compositions médicinales pour traiter les cardiopathies induites par l'hypertrophie cardiaque (par exemple, l'insuffisance cardiaque, les cardiopathies ischémiques et l'arythmie cardiaque). Ces compositions renferment comme principe actif des substances capables de se lier avec GC-A, qui est un récepteur de NP, et de favoriser la production de cGMP. On peut citer parmi ces substances actives les peptides natriurétiques, comme les peptides natriurétiques auriculaires et natriurétiques cérébraux.

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