Medicinal uses of mu-opioid receptor agonists

Details Medicinal uses of mu-opioid receptor agonists Medicinal uses of mu-opioid receptor agonists

A - Human Necessities

61

K

A61K 38/07 (2006.01) A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 38/12 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C07K 14/665 (2006.01) A61K 38/33 (2006.01)

Patent

CA 2416475

The present invention provides methods for stimulating mu-opioid receptors with agonist peptides in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide that comprises at least two .alpha.-amino acid residues. At least one of the amino acid residues has a positive charge. The amino acid residue in the first position is a tyrosine or tyrosine derivative. The amino acid in the second position is a D-.alpha.-amino acid. The present invention also provides methods of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the peptides.

L'invention concerne des procédés de stimulation de peptide agoniste vis-à-vis de récepteur mu-opioïde chez un mammifère, qui consistent à administrer une quantité efficace de ce peptide, lequel comprend au moins deux résidus d'acides .alpha.-aminés. Au moins l'un des résidus a une charge positive. Le résidu dans la première position est une tyrosine ou un dérivé de tyrosine. Le résidu dans la seconde position est un acide D-.alpha.-aminé. L'invention concerne également des procédés relatifs au traitement d'un mammifère souffrant d'affections ou de maladies, par administration d'une quantité efficace de ce type de peptide.

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