C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2406090
Correlations between polymorphisms in the 5-lipoxygenase gene, or polymorphisms in the leukotriene C4 synthase gene, and a subject's phenotypic response to treatment with a leukotriene receptor antagonist for respiratory disease are described. Methods of screening subjects to aid in treatment, and methods of screening therapeutic compounds, are presented.
L'invention concerne des corrélations entre des polymorphismes dans le gène de la 5-lipoxygénase, ou des polymorphismes dans le gène du leucotriène C4 synthase, et la réponse phénotypique d'un sujet à un traitement, à base d'un antagoniste du récepteur du leucotriène, contre une maladie respiratoire. L'invention concerne des méthodes de criblage de sujets destinés à contribuer à ce traitement ainsi que des méthodes de criblage de composés thérapeutiques.
Anderson Wayne H.
Edwards Lisa D.
Emmett Amanda H.
Pillai Sreekumar
Sprankel Catherine S.
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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