Medium-chain length fatty acids, glycerides and analogues as...

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 233/18 (2006.01) A61K 31/19 (2006.01) A61K 31/194 (2006.01) A61K 31/23 (2006.01) A61K 31/255 (2006.01) A61K 31/7024 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61P 7/06 (2006.01) C07H 13/06 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2444463

A composition and method for promoting neutrophil survival and activation such as the treatment of neutropenia arising as an undesirable side effect of chemotherapy and radiation therapy. A composition containing medium-chain fatty acids, such as capri acid or caprylic acid, or salts or triglycerides thereof, or mono- or diglycerides or other analogues thereof or medium-chain triglycerides (MCT) is administered to a human or animal needing treatment in an amount sufficient to reduce or eliminate neutropenia. The composition is administered in an amount effective to treat the disorder. The methods are also useful in the management of bone narrow transplantation and in the treatment of various neutropenic diseases.

Cette invention se rapporte à une composition et à un procédé servant à stimuler la survie et l'activation des neutrophiles, par exemple dans le traitement de la neutropénie apparaissant comme effet secondaire indésirable de la chimiothérapie et de la radiothérapie. Une composition contenant des acides gras à longueur de chaîne moyenne, tels que de l'acide caprique ou de l'acide caprylique, ou des sels ou triglycérides de ces acides, ou des monoglycérides ou diglycérides ou d'autres analogues de ceux-ci ou des triglycérides à longueur de chaîne moyenne (MCT), est administrée à un sujet humain ou animal nécessitant un tel traitement, en quantité suffisante pour réduire ou éliminer la neutropénie. Cette composition est administrée en une quantité propre à traiter le trouble. Ces procédés sont également utiles pour maîtriser une transplantation de moelle osseuse et pour traiter diverses affections neutropéniques.

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