Megakaryocyte and platelet growth, production and composition

Details Megakaryocyte and platelet growth, production and composition Megakaryocyte and platelet growth, production and composition

C - Chemistry, Metallurgy

12

N

C12N 5/02 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2150471

Megakaryocytes and platelets are produced in culture by employing conditions inhibiting the formation of fibroblasts. Particularly, heparin is found to inhibit fibroblasts as well as inactivating factors produced by platelets which inhibit megakaryocyte formation. Isolation of a CD34+41+ cell population which enriches for both megakaryocyte and granulocyte-macrophage progenitors is provided.

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