Meganuclease recombination system

Details Meganuclease recombination system Meganuclease recombination system

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2739849

The invention relates to a set of genetic constructs which allow the efficient and reproducible introduction of a specific nucleotide sequence at a fixed position in the genome by generating a double strand break at a specific position in the genome using a meganuclease and so stimulating a homologous recombination event at this locus between the genomic site and a transfected donor sequence. The present invention also relates to methods using these constructs and to these materials in the form of a kit.

La présente invention concerne un ensemble de constructions génétiques qui permettent lintroduction efficace et reproductible dune séquence nucléotidique spécifique à une position fixe dans le génome par génération dune rupture bicaténaire à une position spécifique dans le génome en utilisant une méganucléase et ainsi stimuler un événement de recombinaison homologue à ce locus entre le site génomique et une séquence donneuse transfectée. La présente invention concerne en outre des procédés utilisant ces constructions et ces matériaux sous la forme dun kit.

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