C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/22 (2006.01)
Patent
CA 2736336
An 1-Crel variant, wherein one of the two 1-Crel monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated respectively from positions 28 to 40 and 44 to 77 of 1-Crel, said variant being able to cleave a DNA target sequence from the Glutamine Synthetase gene. Use of said variant and derived products for improving expression system for the production of recombinant protein.
L'invention porte sur un variant de l-Crel, dans lequel l'un des deux monomères de l-Crel a au moins deux substitutions, une dans chacun des deux sous-domaines fonctionnels du domaine de cur LAGLIDADG situés respectivement des positions 28 à 40 et 44 à 77 de l-Crel, le variant étant apte à cliver une séquence d'ADN cible provenant du gène de la glutamine synthétase. L'invention porte également sur l'utilisation du variant et de produits dérivés destinée à améliorer le système d'expression pour la fabrication d'une protéine recombinée.
Cellectis
Robic
LandOfFree
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