Mek inhibiting oxa- and thia-diazol-2-yl phenylamine...

Details Mek inhibiting oxa- and thia-diazol-2-yl phenylamine... Mek inhibiting oxa- and thia-diazol-2-yl phenylamine...

C - Chemistry, Metallurgy

07

D

C07D 271/113 (2006.01) A61K 31/4245 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 249/08 (2006.01) C07D 249/14 (2006.01) C07D 271/10 (2006.01) C07D 285/135 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2509405

This invention provides substituted Phenyl-(2-[1,3,4]thiadiazol-2-yl~phenyl)- amine and (2-[1,3,4]Oxadiazol-2-yl-phenyl)phenyl-amine compounds which act as inhibitors of MAPKIERK Kinase ("MEK") enzymes and pharmaceutical compositions and methods for their use in immunomodulation and in the treatment and alleviation of inflammation, and proliferative diseases such as cancer and restenosis.

L'invention concerne des composés substitués de phényl-(2-[1,3,4]thiadiazol-2-yl-phényl)-amine et (2-[1,3,4]Oxadiazol-2-yl-phényl)phényl-amine qui fonctionnent comme des inhibiteurs d'enzymes de kinase MAPK/ERK Kinase ("MEK") ainsi que des compositions pharmaceutiques et des procédés de leur utilisation dans l'immunomodulation, pour traiter ou soulager des inflammations et des maladies telles que cancer ou la resténose.

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