Mek inhibitors and methods of their use

Details Mek inhibitors and methods of their use Mek inhibitors and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) C07D 205/06 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2622755

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

La présente invention concerne des composés répondant à la formule (I) et des sels et solvates pharmaceutiquement acceptables de ceux-ci. De tels composés sont des inhibiteurs de MEK utiles dans le traitement de maladies prolifératives, telles que le cancer. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des procédés d'utilisation des composés et des compositions de la présente invention dans le traitement du cancer.

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