Melanin concentrating hormone receptor antagonist

Details Melanin concentrating hormone receptor antagonist Melanin concentrating hormone receptor antagonist

A - Human Necessities

61

K

A61K 31/496 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2533112

Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula (I) wherein A, W, X, Z, R1-R3, and R8 are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula (I).

L'invention concerne de nouveaux composés, ou des sels, des tautomères ou des promédicaments acceptables d'un point de vue pharmaceutique de ceux-ci, représentés par la formule I dans laquelle A, W, X, Z, R?1¿-R?3¿, et R?8¿ sont tels que définis dans les spécifications. L'invention concerne également des méthodes de traitement ou de prévention d'un trouble médié par l'hormone de concentration de la mélanine chez un sujet, consistant à administrer à un sujet en ayant besoin un composé représenté par la formule I.

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