Melanin concentrating hormone receptor ligands: substituted...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/74 (2006.01) C07D 209/86 (2006.01) C07D 211/52 (2006.01) C07D 213/64 (2006.01) C07D 215/12 (2006.01) C07D 215/20 (2006.01) C07D 239/46 (2006.01) C07D 243/08 (2006.01) C07D 295/08 (2006.01) C07D 295/096 (2006.01) C07D 295/108 (2006.01) C07D 295/18 (2006.01) C07D 311/18 (2006.01) C07D 317/58 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2448080

Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl- piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptir activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

Cette invention concerne des ligands récepteurs de l'hormone de concentration de la mélanine (MCH) (en particulier 1-benzyl-4-aryl-pipérazines, 1-benzyl-4-aryl-pipéridines et composés connexes) capables de moduler l'activité des récepteurs de MCH. De tels ligands, qui peuvent s'utiliser pour moduler la liaison MCH avec des récepteurs de MCH in vivo ou in vitro, conviennent particulièrement bien pour le traitement de divers troubles du métabolisme, de l'alimentation et d'ordre sexuel chez l'homme, les animaux domestiques de compagnie et le bétail. L'invention porte sur des compositions pharmaceutiques et des méthodes de traitement desdits troubles ainsi que des méthodes d'utilisations de tels ligands pour la détection de récepteurs de MCH (telles que des études de localisation de récepteurs).

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