Melanin production by transformed organisms

Details Melanin production by transformed organisms Melanin production by transformed organisms

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C07K 2/00 (2006.01) C07K 14/36 (2006.01) C07K 19/00 (2006.01) C09B 61/00 (2006.01) C12N 9/02 (2006.01) C12N 15/31 (2006.01) C12P 1/04 (2006.01) C12P 17/00 (2006.01)

Patent

CA 2086417

The present invention is directed to a process for producing melanins, their precursors and their analogs, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 0.2 grams dry weight per liter of growth medium. The enhanced production of melanin can be achieved by manipulating the constituents of the growth medium, and/or attenuating fermentation conditions, and/or by genetically engineering microorganism to produce melanins, and/or mutating the microorganisms.

Procédé de production de mélanines, de leurs précurseurs et de leurs analogues, dont l'appellation générique est mélanines. Selon l'invention, on produit des mélanines dans des quantités supérieures – environ 0,2 grammes en poids sec par litre de milieu de croissance. On peut parvenir – une production accrue de mélanine par manipulation des constituants du milieu de croissance, et/ou atténuation des conditions de fermentation, et/ou par mise au point de microorganismes obtenus par génie génétique afin de produire des mélanines, et/ou en soumettant les microorganismes – une mutation.

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