Melanocortin-4 receptor binding compounds and methods of use...

Details Melanocortin-4 receptor binding compounds and methods of use... Melanocortin-4 receptor binding compounds and methods of use...

C - Chemistry, Metallurgy

07

D

C07D 235/06 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/505 (2006.01) A61P 3/04 (2006.01) C07D 233/20 (2006.01) C07D 235/18 (2006.01) C07D 239/06 (2006.01)

Patent

CA 2381008

MC4-R binding compounds of the formula (I): B-Z-E wherein B is an anchor moiety, Z is a central moiety, and E is an MC4-R interacting moiety are discussed. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also discussed.

Cette invention se rapporte à des composés fixant les récepteurs MC4-R, ces composés étant représentés par la formule: B-Z-E (I), où B représente une fraction d'ancrage, Z représente une fraction centrale et E représente une fraction interagissant avec les récepteurs MC4-R. Des procédés d'utilisation de ces composés pour traiter les maladies associées aux récepteurs MC4-R, telles que les troubles associés à la perte de poids, sont également décrits.

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