Melanocortin-4 receptor deficient cells, non-human...

A - Human Necessities – 01 – K

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A01K 67/00 (2006.01) C07K 14/72 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2390740

Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-4 receptor protein (MC-4R). These MC-4R deficient transgenic animals can be used to select for and test potential modulators of MC-4R. This data allows for methods of screening for preferential MC-4R modulators which effect body weight through modulation of both metabolic rate and food intake, as well as associated methods of treating various disorders associated with inappropriate regulation of body weight.

La présente invention concerne des cellules et des animaux transgéniques non humains qui ont été mis au point pour être déficients en gène codant la protéine de récepteur 4 de mélanocortine (MC-4R). Ces animaux transgéniques présentant une déficience en MC-4R peuvent être utilisés, afin de sélectionner et de tester des modulateurs potentiels de MC-4R. Ces données permettent de mettre en oeuvre des procédés de criblage de modulateurs de MC-4R préférentiels, qui agissent sur le poids corporel par modulation à la fois de la vitesse de métabolisme et de l'absorption d'aliments, ainsi que des procédés associés de traitement de divers troubles associés à une régulation inappropriée du poids corporel.

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