Melanocortin receptor ligands

Details Melanocortin receptor ligands Melanocortin receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 241/08 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 31/445 (2006.01) A61K 31/45 (2006.01) A61K 31/496 (2006.01) C07D 207/12 (2006.01) C07D 211/40 (2006.01) C07D 211/46 (2006.01) C07D 211/56 (2006.01) C07D 215/06 (2006.01) C07D 241/04 (2006.01) C07D 241/06 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2444599

Disclosed are MC-3/MC-4 receptor ligands, the ligands having the formula (I) wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbocyclic rings; b) aromatic carbocyclic rings; c) non-aromatic heterocyclic rings; d) aromatic heterocyclic rings; wherein said rings comprises from 5 to 8 atoms; and W is a unit which preferable comprises D-1-fluorophenyalanine, Y comprises a heteroatom, and Z comprises an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the invention as well as methods of treating diseases mediated through MC-3/MC-4 receptors.

L'invention concerne des ligands récepteurs MC-3/MC-4, caractérisés en ce que les ligands ont la formule (I) dans laquelle A désigne un système cyclique de structure limitée, choisi dans le groupe comprenant a) des noyaux carbocycliques non aromatiques ; b) des noyaux carbocycliques aromatiques ; c) des noyaux hétérocycliques non aromatiques ; d) des noyaux hétérocycliques aromatiques ; où lesdits noyaux comprennent de 5 à 8 atomes ; et W désigne un motif comprenant de préférence de la D-1-fluorophénylalanine, Y renferme un hétéroatome, et Z renferme un noyau carbocyclique aromatique. L'invention concerne également des compositions pharmaceutiques comprenant les ligands de l'invention, ainsi que des procédés de traitement de maladies occasionnées par des récepteurs MC-3/MC-4.

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