Melanocortin receptor ligands

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/16 (2006.01) A61K 31/445 (2006.01) A61P 3/04 (2006.01) C07D 211/26 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2483787

The present invention relates to compounds which comprise a 4-substituted piperidine ring linked to a substituted or unsubstituted hydrocarbyl ring. The compounds, including all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula (I): wherein preferably R is substituted aryl, W is a pendant unit having the formula -L-Q: L is a linking unit, Q is preferably a cyclic hydrocarbyl unit; W1 is preferably a carbocyclic unit and W2 is a heteroatom comprising unit.

La présente invention se rapporte à des composés qui comportent un anneau pipéridine 4-substitué lié à un anneau hydrocarbyle substitué ou non substitué. Ces composés, notamment toutes les formes énantiomères et diastéromères et les sels pharmaceutiquement acceptables de ces formes, présentent la formule (I), dans laquelle R est de préférence aryle substitué, W est une unité latérale ayant la formule: -L-Q, L étant une unité de liaison, Q étant de préférence une unité hydrocarbyle cyclique; W?1¿ est de préférence une unité carbocyclique et W?2¿ est une unité comprenant un hétéroatome.

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