G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) A61K 39/00 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2381099
An epitope of high molecular weight melanoma associated antigen (HMW-MAA) displayed on the surface of human cells but not cells from Macaca fascicularis is described, said epitope a) having the ability of being specifically blocked by and specifically block a binding structure which recognizes HMW-MAA, b) being displayed on the surface of human cells but not cells from Macaca fascicularis, and c) having a normal tissue distribution pattern which is more restricted than that of other known epitopes of HMW-MAA. There is also described a binding structure and antibodies recognizing target structures of said antigen, pharmaceutical compositions and vaccines as well as methods of using said epitopes and antibodies in diagnostic and therapeutic methods related to human malignant diseases.
L'invention concerne un épitope d'un antigène associé à un mélanome de poids moléculaire élevé (HMW-MAA) présenté sur la surface de cellules humaines mais pas de Macaca fascicularis, a) pouvant être bloqué spécifiquement et bloquant spécifiquement une structure de liaison reconnaissant HMW-MAA, b) présenté sur la surface de cellules humaines et pas de Macaca fascicularis, et c) possédant une distribution tissulaire normale, plus restreinte que celle d'autres épitopes de HMW-MAA connus. L'invention concerne également une structure de liaison et des anticorps reconnaissant les structures cible dudit antigène, des compositions pharmaceutiques et des vaccins ainsi que des procédés d'utilisation desdits épitopes et anticorps dans des diagnostics et des thérapies liés aux affections malignes humaines.
Brodin Thomas N.
Ohlsson Lennart G.
Tordsson M. Jesper
Active Biotech Ab
Gowling Lafleur Henderson Llp
LandOfFree
Melanoma associated antigen (hmw-maa) defined by a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Melanoma associated antigen (hmw-maa) defined by a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Melanoma associated antigen (hmw-maa) defined by a... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1486334