C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/18 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2142575
The present invention describes a melanoma associated antigen known as gp100. Furthermore, peptides derived form said antigen are claimed. Gp100 and its peptides can be used in vaccines for the treatment of melanoma. Another aspect of the invention are host cells capable of expression of gp100 or the gp100-derived peptides. Furthermor, tumor infiltrating lymphocytes (TIL's) specifically recognizing gp100 are claimed, as are vaccines with these TIL's. Furthermore, diagnostics for the detection of melanoma and for the monitoring of vaccination form part of the invention.
La présente invention porte sur un antigène associé au mélanome appelé gp100. Par ailleurs, des peptides dérivés dudit antigène sont aussi revendiqués. Gp100 et ses peptides peuvent être utilisés dans des vaccins pour le traitement du mélanome. Un autre aspect de l'invention concerne des cellules hôte capables d'exprimer gp100 ou des peptides dérivés de gp100. En outre, des lymphocytes infiltrant les tumeurs reconnaissant spécifiquement gp100 sont revendiqués, de même que des vaccins faisant appel à ces lymphocytes. Des méthodes diagnostiques permettant la détection de mélanomes et la surveillance de la vaccination font aussi partie de l'invention.
Adema Gosse J.
Figdor Carl G.
Akzo Nobel N.v.
Department Of Health And Human Services Government Of The United States Of America As Represented By The
Fetherstonhaugh & Co.
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