C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 5/077 (2010.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2259944
The present invention is concerned with cancer treatment and diagnosis, especially with melanoma associated peptide analogues with improved immunogenicity, epitopes thereof, vaccines against melanoma, tumour infiltrating T lymphocytes recognizing the antigen and diagnostics for the detection of melanoma and for the monitoring of vaccination. The peptides according to the invention can be exploited to elicit native epitope-reactive CTL. Usage of said peptides with improved immunogenicity may contribute to the development of CTL-epitope based vaccines in viral disease and cancer.
La présente invention concerne le traitement et le diagnostic du cancer, et plus particulièrement des analogues de peptides associés à un mélanome dotés d'une immunogénicité accrue, des épitopes de ces derniers, des vaccins contre le mélanome, des lymphocytes T infiltrant des tumeurs et identifiant l'antigène, et des diagnostics permettant de détecter un mélanome et de surveiller une vaccination. Les peptides selon l'invention peuvent être exploités pour éliciter des lymphocytes T cytotoxiques endogènes. L'utilisation de ces peptides dotés d'une immunogénicité accrue peut contribuer au développement de vaccins basés sur des épitopes de lymphocytes T cytotoxiques dans les maladies virales et le cancer.
Adema Gosse Jan
Figdor Carl Gustav
Borden Ladner Gervais Llp
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Introgene B.v.
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