Melatonin tablet and methods of preparation and use

Details Melatonin tablet and methods of preparation and use Melatonin tablet and methods of preparation and use

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/70 (2006.01) A61K 47/32 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2683436

The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.

L'invention concerne une composition pharmaceutique pour une administration par voie sublinguale ou orale d'agents actifs présentant une faible ou une médiocre solubilité aqueuse, par exemple l'hormone indolique mélatonine, qui contient une solution de l'agent actif dans un solvant pharmaceutiquement acceptable adsorbé ou absorbé sur des particules d'un excipient pharmaceutiquement acceptable et des procédés de préparation et d'utilisation de la composition pharmaceutique.

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