C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/06 (2006.01) A61K 31/473 (2006.01) A61K 31/551 (2006.01) A61K 31/661 (2006.01) A61P 35/00 (2006.01) C07D 487/06 (2006.01) C07F 9/12 (2006.01)
Patent
CA 2599611
The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.
Cette invention concerne des composés de pyrroloquinolinyl-pyrrole-2,5-dione et des composés de pyrroloquinolinyl-pyrrolidine-2,5-dione ainsi que des procédés de préparation de ces composés. Cette invention concerne également des compositions pharmaceutiques renfermant des composés pyrroloquinolinyl-pyrrole-2,5-dione et des composés pyrroloquinolinyl-pyrrolidine-2,5-dione. Cette invention concerne des méthodes de traitement de troubles liés à la prolifération cellulaire tels qu'un cancer, par l'administration à un patient nécessitant un tel traitement, d'une dose thérapeutiquement efficace d'un composé de pyrroloquinolinyl-pyrrole-2,5-dione ou d'un composés de pyrroloquinolinyl-pyrrolidine-2,5-dione de la présente invention.
Ashwell Mark Antony
Hill Jason
Li Chiang J.
Moussa Magdi M.
Munshi Neru
Arqule Inc.
Mbm Intellectual Property Law Llp
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