A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 47/34 (2006.01)
Patent
CA 2188785
Sucralfate preparation produced by melt granulating a mixture of a comminuted sucralfate powder and a water-soluble low-melting point wax, as well as a process for producing a sucralfate preparation comprising the steps of comminuting dry sucralfate into fine particles, mixing the finely divided particles with a water-soluble low-melting point wax and heating the mixture such that the wax is melted to effect melt (adhesion) granulation of the finely divided sucralfate particles are disclosed. Compared to conventional sucralfate preparations, the thus produced sucralfate preparation has a small dispersed particle size, exhibits high capability for binding to plasma proteins and thereby achieves marked improvements in administrability and protein binding capability.
Préparation de sucralfate obtenue par granulation à chaud d'un mélange de poudre de sucralfate avec une cire hydrosoluble à bas point de fusion; et procédé de production d'une préparation de sucralfate par atomisation de sucralfate sec, addition d'une cire hydrosoluble à bas point de fusion dans la poudre atomisée, et fusion à chaud de la cire pour obtenir une granulation à chaud du sucralfate atomisé. A la différence des préparations de sucralfate classiques, la préparation selon l'invention comprend des particules dispersées de taille moins importante, est plus facile à administrer et présente une capacité de liaison élevée avec les protéines plasmatiques, ainsi qu'une capacité de liaison améliorée des protéines.
Matsuda Katsuya
Ozawa Koichi
Chugai Seiyaku Kabushiki Kaisha
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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