Melt-processed imatinib dosage form

Details Melt-processed imatinib dosage form Melt-processed imatinib dosage form

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2668775

The invention provides a dosage form, comprising a melt-processed mixture of (a) a pharmaceutically effective amount of imatinib or a salt thereof, (b) at least one polymeric binder, and (c) at least one pharmaceutically acceptable non-ionic surfactant. The invention provides imatinib dosage forms with high drug loading which can be prepared in a simple and efficient manner, imatinib dosage forms from which the active principle is released in an essentially pH-independent fashion, and extended release imatinib dosage forms.

La présente invention concerne une forme pharmaceutique qui comprend un mélange traité à l'état fondu de (a) une quantité pharmaceutiquement efficace d'imatinib ou d'un sel de celui-ci, (b) au moins un liant polymère et (c) au moins un tensioactif non ionique pharmaceutiquement acceptable. L'invention concerne des formes pharmaceutiques d'imatinib à charge médicamenteuse élevée qui peuvent être préparées d'une manière simple et efficace, des formes pharmaceutiques d'imatinib à partir desquelles le principe actif est libéré d'une manière pratiquement indépendante du pH et des formes pharmaceutiques d'imatinib à libération prolongée.

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