C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/10 (2006.01) G01N 33/557 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2623268
A system and methods are provided for melting curve genotyping analysis of nucleic acids. Melting curves are generated by plotting fluorescence of a sample as a function of temperature. In one illustrative example, an exponential algorithm is employed to remove the background from generated melting curves and thereby perform comparative analysis to other melting curves. Additional illustrative examples provide for measuring the differences between two or more melting curves and clustering the genotypes of the provided sample nucleic acids.
L'invention concerne un système et des procédés destinés à une analyse par génotypage de courbe de fusion, d'acides nucléiques. Les courbes de fusion sont générées par tracé graphique de la fluorescence d'un échantillon comme une fonction de température. Dans un exemple cité, un algorithme exponentiel est utilisé pour retirer le fond des courbes de fusion générées et ainsi réaliser une analyse par comparaison à d'autres courbes de fusion. L'invention donne des exemples additionnels pour mesurer les différences entre au moins deux courbes de fusion et regrouper les génotypes des acides nucléiques échantillons.
Palais Robert Andrew
Wittwer Carl Thomas
Torys Llp
University Of Utah Research Foundation
LandOfFree
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