Meltrins

Details Meltrins Meltrins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247067

The purpose of the present invention is to provide a novel protein involved in adhesion and fusion between myoblasts in the course of the formation of byotube. The present invention relates to Meltrins, which a membrane protein having fusion, adhesion and aggregation activity of cells, especially myoblast; and to polypeptides of their domains, DNAs encoding them, antisense RNA for these DNAs, various antibodies to Meltrins and the polypeptides of their domains, expression vectors containing these DNAs, and transfomants by these vectors; as well as to the process for producing Meltrins and the polypeptides of their domains using those transformants and medical compositions comprising Meltrins or antagonist against them as an effective ingredient.

Cette invention se rapporte à de nouvelles substances qui participent à l'adhésion et à la fusion des myoblastes entre eux au cours de la formation des myotubes et elle concerne des meltrines qui sont des protéines membranaires jouant un rôle au niveau de la fusion, de l'adhésion ou de l'agglutination des cellules, et notamment des myoblastes, des polypeptides des domaines respectifs de ces meltrines, des ADN codant ces meltrines, des ARN antisens associés à ces ADN, divers anticorps dirigés contre ces meltrines et les polypeptides de celles-ci, des vecteurs d'expression contenant les ADN, des transformants construits au moyen des vecteurs d'expression, un procédé de fabrication des meltrines susmentionnées et des polypeptides au moyen des transformants, et des compositions médicinales contenant ces meltrines ou des antagonistes de meltrines en tant que principe actif.

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