A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2505374
The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be used as models to study heart pathologies and provide therapies thereof, wherein the heart pathologies are heart failure, and in particular diluted cardiomyopathy.
L'invention concerne des animaux transgéniques non humains constituant un modèle d'étude de pathologies humaines, qui sont transgéniques en ce qu'ils présentent une expression modifiée de la mélusine. Ces animaux transgéniques non humains sont destinés à servir de modèles pour l'étude de pathologies cardiaques et la recherche de thérapies de celles-ci. Par pathologies cardiaques, on entend l'insuffisance cardiaque, et en particulier la cardiomyopathie dilatée.
Altruda Fiorella
Brancaccio Mara
Fratta Luigi
Lembo Giuseppe
Silengo Lorenzo
Macrae & Co.
Universita Degli Studi Di Torino
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