Membrane affinity apparatus and purification methods related...

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B01D 63/02 (2006.01) B01D 61/00 (2006.01) B01D 63/04 (2006.01) B01D 63/08 (2006.01) B01D 69/08 (2006.01) B01J 16/00 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2001720

The invention relates to an apparatus useful for the separation of at least one preselected ligate present in a fluid. The invention also features an easily scaled-up membrane affinity separtion process which is highly reliable, highly selective, provides a high yield of product, and is further characterized by a high volumetric throughput. The invention utilizes a substantially isotropic porous membrane, to which is associated a preselected ligand, which provides an optimum loading capacity and low dead volume while allowing high filtrate flow rates. Methods for isolating macromolecules having therapeutic value are described.

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