Membrane anchor/active compound conjugate, its preparation...

Details Membrane anchor/active compound conjugate, its preparation... Membrane anchor/active compound conjugate, its preparation...

C - Chemistry, Metallurgy

07

K

167/103, 167/129

C07K 7/06 (2006.01) A61K 9/127 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) B01J 20/32 (2006.01) C07C 233/31 (2006.01) C07K 5/00 (2006.01) C07K 5/093 (2006.01) C07K 7/08 (2006.01) C07K 14/555 (2006.01) C07K 14/71 (2006.01) C07K 17/02 (2006.01) G01N 33/532 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340656

A description is given of membrane anchor/active compound conjugates in which the active compound is covalently bonded to the membrane anchor which is a compound of the formulae (see fig. I to VII) it being possible for A to be sulfur, oxygen, disulfide (-S-S-), methylene (-CH2-) or -NH-; n being 0 to 5; m being 1 or 2; B can be each of the substituted s-alkyl radicals formulated in I to V; C* being an asymmetric carbon atom with R or S configuration; R, R' and R" being identical or different and being an alkyl, alkenyl or alkynyl group having 7 to 25 carbon atoms or hydrogen, which can optionally be substituted by hydroxyl, amino, oxo, acyl, alkyl or cycloalkyl groups, and R1 and R2 being identical or different and being defined as R, R' and R" or possibly being -OR, -OCOR, -COOR, -NHCOR or -CONHR, and X being an active compound or a spacer-active compound group. The membrane anchor/active compound conjugates increase the formation of antibodies.

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