B - Operations – Transporting – 01 – D
Patent
B - Operations, Transporting
01
D
B01D 61/24 (2006.01) A61K 39/395 (2006.01) B01D 61/36 (2006.01) C07K 16/06 (2006.01)
Patent
CA 2754393
The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the inven-tion include membrane evaporation, such as evaporation of protein-free sol-vent from the protein solution, which concentrates the protein. The methods of the present invention result in protein solution concentrations not previously achievable by conventional ultrafiltra-tion methods, e.g., protein solution con-centrations of greater than about 260 grams of protein per liter of solution.
La présente invention concerne des procédés de génération de solutions protéiques très concentrées, par exemple, une solution d'anticorps, une solution protéique thérapeutique, etc. Les procédés de l'invention comprennent l'évaporation à travers une membrane, par exemple l'évaporation d'un solvant sans protéine de la solution protéique, qui entraîne la concentration de la protéine. Les procédés de la présente invention résultent en des concentrations de la solution protéique jamais obtenues jusqu'à présent à l'aide des procédés d'ultrafiltration classiques, par exemple, des concentrations de la solution protéique supérieures à environ 260 grammes de protéine par litre de solution.
Acharya Hari
Boesch Austin Wayne
Bolton Glen Reed
Torys Llp
Wyeth Llc
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