Membrane fusion protein

Details Membrane fusion protein Membrane fusion protein

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/14 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01)

Patent

CA 2429891

A family of membrane fusion proteins and polynucleotides encoding the proteins have been identified. The proteins and polynucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p22 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.

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