Membrane-permeant peptide complexes for medical imaging,...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/16 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C12N 9/64 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2328457

Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.

La présente invention concerne des procédés et des compositions utilisées dans l'imagerie médicale, l'évaluation des processus et composants intracellulaires, la radiothérapie de cibles intracellulaires, et l'administration de médicaments, qui font appel à des complexes de coordination de conjugués peptidiques de perméation de membrane cellulaire et à des complexes covalents présentant une spécificité de cellule cible. L'invention se rapporte également à des trousses permettant de conjuguer des radionucléides et d'autres métaux avec des complexes de coordination de peptides.

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