C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2174081
A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability, and a novel membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell growth-supporting ability or a part of it. A method for producing said novel membrane protein polypeptide by preparing transformants by transforming a host cell with a vector containing said gene and culturing said transformants. A monoclonal antibody recognizing said novel membrane protein polypeptide. The above gene encodes the membrane protein having pre-B cell growth-supporting ability. The homogeneous and purified novel membrane protein polypeptide can be produced in large quantities and in addition, monoclonal antibodies recognizing said polypeptide can be produced; thus it becomes possible to identify rheumatoid arthritis (RA) and also prepare reagents for the clinical diagnosis thereof.
L'invention concerne un gène codant un nouveau polypeptide de protéine membranaire présentant une fonction de soutien de la croissance des cellules pré-B, un nouveau polypeptide de protéine membranaire présentant une fonction de soutien de la croissance des cellules pré-B et comprenant tout ou partie d'une séquence de 180 restes d'acides aminés, un procédé de production dudit peptide par transformation des cellules hôtes avec un vecteur contenant le gène susmentionné et la mise en culture du transformant ainsi obtenu, ainsi qu'un anticorps monoclonal reconnaissant ledit nouveau peptide. Le gène selon l'invention code pour une protéine membranaire présentant une fonction de soutien de la croissance de cellules pré-B. Le procédé selon l'invention permet la production de masse d'un nouveau polypeptide de protéine membranaire uniforme ainsi que la production d'un anticorps monoclonal reconnaissant le polypeptide. Il est ainsi possible de préparer un réactif pour l'identification et le diagnostic clinique de l'arthrite rhumatoïde.
Hirano Toshio
Kaisho Tsuneyasu
Hirano Toshio
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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