C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/50 (2006.01) A61K 9/127 (2006.01) A61K 9/51 (2006.01) A61K 38/28 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2386231
The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active particle complex. The MTLP or the nucleotide sequence coding therefor enhance movement of the active agent or of the active particle across a lipid membrane. More particularly, the present invention relates to an MTLP-active agent complex and an MTLP-active particle complex, wherein the MTLP enhances uptake of the active agent into a cell, into or out of an intracellular compartment and across a cell layer. Methods of making and methods of using MTLPs also are included.
L'invention concerne une nouvelle séquence peptidique de translocation membranaire, son fragment, motif, dérivé, analogue ou peptidomimétique (MTLP), des séquences nucléotidiques codant pour le peptide et des compositions comprenant un complexe de principe actif MTLP et un complexe particulaire actif MTLP. Le MTLP ou la séquence nucléotidique codant pour le peptide améliorent le mouvement du principe actif ou de la particule active à travers une membrane lipidique. L'invention concerne plus particulièrement un complexe de principe actif MLTP et un complexe particulaire actif MTLP, le MTLP améliorant l'absorption du principe actif dans une cellule, dans ou hors d'un compartiment intracellulaire et à travers une couche cellulaire. L'invention concerne aussi des procédés de fabrication et les applications des MTLP.
Lambkin Imelda J.
O'mahony Daniel J.
Elan Pharma International Limited
Lambkin Imelda J.
O'mahony Daniel J.
Ridout & Maybee Llp
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